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gastric mass

Practice targeted AMC-style multiple-choice questions on gastric mass.

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Hepatic metastases from a gastric mixed adenoneuroendocrine carcinoma (MANEC).
Image by Hellerhoff CC BY-SA 3.0 · Source

A 65-year-old male presents with a 3-month history of unintentional weight loss and epigastric discomfort. Endoscopy revealed a gastric mass, and biopsy confirmed a mixed adenoneuroendocrine carcinoma. Staging imaging is shown. His ECOG performance status is 1. Considering the clinical presentation and the findings demonstrated in the provided images, what is the most appropriate initial management strategy for this patient?

A. Commence treatment with a long-acting somatostatin analogue
B. Plan for palliative external beam radiotherapy to the liver
C. Initiate systemic chemotherapy targeting the adenocarcinoma component
D. Refer for surgical assessment for hepatic metastasectomy
E. Evaluate for potential liver transplantation
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Hepatic metastases from a gastric mixed adenoneuroendocrine carcinoma (MANEC).
Image by Hellerhoff CC BY-SA 3.0 · Source

A 65-year-old male presents with a 2-month history of fatigue, poor appetite, and 5kg weight loss. He reports mild upper abdominal discomfort. Physical examination is unremarkable. Initial blood tests show mild anaemia. An upper endoscopy revealed a suspicious gastric lesion, with biopsy results pending. A CT scan of the abdomen and pelvis was performed. Given the clinical presentation and the findings on the provided imaging, which of the following statements regarding this patient's likely prognosis and management is most accurate?

A. Referral for surgical assessment for potential hepatectomy is the next appropriate step.
B. The extensive nature of the findings suggests limited options for curative treatment, with systemic therapy typically employed for palliation or disease control.
C. Liver-directed therapies such as transarterial chemoembolisation (TACE) should be pursued.
D. The findings are likely benign and require no further intervention beyond managing the primary gastric lesion.
E. A watch-and-wait approach with repeat imaging in 3-6 months is recommended.
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